Author Topic: (AAN) Lower 25-hydroxyvitamin D levels compared to bioavailable vitamin D  (Read 91 times)

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Offline agate

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Presented at the recent annual AAN conference in Washington, DC:

Quote
[P2.208] Lower 25-hydroxyvitamin D levels in patients with a clinically isolated syndrome compared to healthy controls are not associated with lower levels of bioavailable vitamin D

Janina Behrens, Ludwig Rasche, Rene Giess, Catherina Pfuhl, Katharina Wakonig, Eric Freitag, Katrin Deuschle, Judith Bellmann-Strobl, Friedemann Paul, Klemens Ruprecht, Jan Dörr

Berlin, Germany

OBJECTIVE:

To analyze levels of 25-hydroxyvitamin D (25[OH]D) and bioavailable vitamin D in patients with a clinically isolated syndrome (CIS) compared to healthy controls.

BACKGROUND:

 Low 25(OH)D levels correlate with higher disease activity in patients with multiple sclerosis (MS), but could merely represent a consequence of MS. Furthermore, bioavailable vitamin D could be a biologically more relevant parameter than 25(OH)D, but has hitherto not been studied in patients with early MS.

DESIGN/METHODS:

We measured serum concentrations of 25(OH)D2, 25(OH)D3, vitamin D binding protein (DBP), and albumin, and calculated with these values the percentage of bioavailable and free vitamin D in 76 patients with CIS and 76 age- and gender-matched healthy controls (HC). 25(OH)D3 levels were de-seasonalized before analyses.

RESULTS:

25(OH)D3 levels were lower in patients with CIS compared to HC (p=0.002) and more patients with CIS (8/76, 10,5 %) than HC (1/76, 1,3%) had 25(OH)D3 levels <25nmol/l (p=0.03). In contrast, levels of 25(OH)D2, DBP, albumin, and calculated levels of free and bioavailable VD did not differ between both groups. 25(OH)D3 concentrations were neither correlated with temporal distance (days) from the previous relapse (r=-0.107, p=0.36) nor with DBP levels in patients (r=0.18, p=0.13) and in HC (r=0.11, p=0.35)

CONCLUSION:

While the detection of lower 25(OH)D levels in patients with CIS supports a role of low 25(OH)D levels as a risk factor for MS, the mechanism underlying the association of 25(OH)D and MS does not appear to be related to reduced bioavailable vitamin D levels.

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Category - MS and CNS Inflammatory Disease: Clinical Science

Session: P2: Poster Session II: MS and CNS Inflammatory Diseases: Risk Factors for MS Disease and Course (7:30 AM-12:00 PM)
Date/Time: Tuesday, April 21, 2015 - 7:30 am

The abstract can be seen here.
MS Speaks--online for 17 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week) since 12/16/20.