Author Topic: (Abst.) Health care use before a first demyelinating event suggests MS prodrome...  (Read 28 times)

0 Members and 0 Guests are viewing this topic.

Offline agate

  • Administrator
  • *****
  • Posts: 8218
  • MS diagnosed 1980
  • Location: Pacific Northwest
From PubMed, April 25, 2017:

Quote
Lancet Neurol. 2017 Apr 20.

Health-care use before a first demyelinating event suggestive of a multiple sclerosis prodrome: a matched cohort study

Wijnands JMA1, Kingwell E1, Zhu F1, Zhao Y1, Högg T2, Stadnyk K3, Ekuma O4, Lu X5, Evans C6, Fisk JD7, Marrie RA8, Tremlett H9.
Author information

1
Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada.
2
Department of Statistics, University of British Columbia, Vancouver, BC, Canada.
3
Nova Scotia Health Authority, Halifax, NS, Canada.
4
Manitoba Centre for Health Policy, University of Manitoba, Winnipeg, MB, Canada.
5
Health Quality Council, Saskatoon, SK, Canada.
6
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.
7
Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada; Department of Medicine, Dalhousie University, Halifax, NS, Canada.
8
Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
9
Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada. Electronic address: helen.tremlett@ubc.ca.

BACKGROUND:

Degenerative processes in neurodegenerative diseases can start years before clinical manifestation. We aimed to establish whether a multiple sclerosis prodromal period exists by examining patterns of health-care use before a first demyelinating event.

METHODS:

In this matched cohort study, we used data from linked health administrative and clinical databases from four Canadian provinces (British Columbia, Saskatchewan, Manitoba, and Nova Scotia) to compare hospital, physician, and prescription use data from people with multiple sclerosis and matched general population controls in the 5 years before the first demyelinating disease claim (health administrative index date) or clinically reported symptom onset (clinical index date). Rate ratios (RRs) were estimated using negative binomial regression and combined across provinces using random effect models. The primary outcome was all-cause use of health care during each of the 5 years before the health administrative or clinical index date.

FINDINGS:

The health administrative cohort included 14,428 multiple sclerosis cases and 72,059 matched controls for whom data were available between April, 1984, and April, 2014.

Annual health-care use increased steadily between 5 years and 1 year before the first demyelinating disease claim in people with multiple sclerosis compared with controls (from RR 1·26 [95% CI 1·16-1·36] to 1·78 [1·50-2·10] for hospital admissions; from 1·24 [1·16-1·32] to 1·88 [1·72-2·07] for physician claims; and from 1·23 [1·06-1·41] to 1·49 [1·41-1·59] for prescriptions, assessed as drug classes). Similar patterns for physician claims and prescriptions were observed in the cohort with available clinical symptom onset (3202 individuals with multiple sclerosis and 16 006 controls), although the differences in use in each of the 5 years mostly did not reach statistical significance.

INTERPRETATION:

More frequent use of health care in patients with multiple sclerosis than in controls in the 5 years before a first demyelinating event, according to health administrative data, suggests the existence of a measurable multiple sclerosis prodrome. These findings have clinical and research implications, including the establishment of an earlier window of opportunity to identify and potentially treat multiple sclerosis.

FUNDING:

National Multiple Sclerosis Society.

The abstract can be seen here.
MS Speaks--online for 13 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010.

 

Related Topics