MS Speaks

Multiple Sclerosis => TREATMENTS => TYSABRI (natalizumab) => Topic started by: agate on March 26, 2017, 01:51:38 pm

Title: Tysabri-related PML cases
Post by: agate on March 26, 2017, 01:51:38 pm
New data reveal that as of March 6, 2017, there have been 714 confirmed Tysabri-related PML cases worldwide, with 711 of them in persons with MS and 3 in persons with Crohn's disease.

As of February 28, 2017, overall PML incidence was 4.20 per 1000 patients (95% CI 3.89 to 4.52 per 1000 patients). 23% of the patients have died; 77% of patients are alive with varying levels of disability.

As of February 28, 2017, approximately 167,300 patients received Tysabri in a post-marketing setting, worldwide.
Title: 711 cases of Tysabri-related PML in persons w/MS
Post by: ssalimi on April 02, 2017, 02:30:21 pm
What was the source for this?
Title: Re: 711 cases of Tysabri-related PML in persons w/MS
Post by: agate on April 02, 2017, 03:28:06 pm
https://chefarztfrau.de/?page_id=716 (https://chefarztfrau.de/?page_id=716)

This is an unofficial source but apparently this guy (named Alexander Otto) in Germany has access to the correct information because he's been posting the data correctly for many years.
Title: 718 PML cases for PwMS as of 6/6/17, 24% have died
Post by: agate on June 26, 2017, 12:14:18 pm
Updated, from the same source
:
Quote
As of June 06. 2017, there have been 731 (728 MS, 3 CD) confirmed PML cases worldwide.

As of May 31, 2017, overall PML incidence: 4.21 per 1000 patients (95% CI 3.91 to 4.52 per 1000 patients). 24% of patients have died; 76% of patients are alive with varying levels of disability.
As of May 31, 2017, approximately 170,900 patients received natalizumab in post-marketing setting worldwide.
Title: 801 confirmed PML cases in MS patients on Tysabri (Dec. 2018)--Filgastrim for PML?
Post by: agate on June 18, 2019, 08:25:47 pm
The informal source that has been recording Tysabri-related PML cases in MS patients hasn't been updated in over a year. However, this article in Multiple Sclerosis News Today (June 28, 2019) reveals that as of 12/18, the total number of PML cases in MS patients on Tysabri was 801.  The article is about a possible treatment for PML, filgrastim, and is entitled "Filgrastim Likely Beneficial for Patients with Tysabri-Associated PML":


https://multiplesclerosisnewstoday.com/filgastrim-beneficial-patients-tysabri-associated-pml/