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MISCELLANEOUS / Paleo diet may be bad for heart health
« Last post by agate on July 23, 2019, 07:53:47 pm »
From Medical News Today (July 23, 2019)--"Paleo diet may be bad for heart health":


http://bit.ly/2JMLklT


The Wahls diet, created by Dr. Terry Wahls, who has claimed to have cured her MS, is a variant of the Paleo diet. WebMD recommends a cautious approach to the Wahls diet:


https://www.webmd.com/multiple-sclerosis/wahl-diet-ms
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From Medical News Today, July 22, 2019--"When's the best time to take a warm bath for better sleep?"


http://bit.ly/2YrXBog
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Sometimes there can be MS-related dementia, and some people with MS can also develop Alzheimer's disease. I just watched a grim final episode of the TV series "Wallander" where the main character is shown being diagnosed with Alzheimer's disease and progressing with it. So this article seemed appropriate just now--from NEJM Journal Watch (July 15, 2019):


Quote
Could Healthy Lifestyle Help Those at High Genetic Risk for Dementia?

By Kelly Young
Edited by Susan Sadoughi, MD, and Andre Sofair, MD, MPH

Adherence to a healthy lifestyle is associated with reduced risk for dementia, even among those who are genetically predisposed, according to a JAMA study presented at the Alzheimer's Association International Conference.
Nearly 200,000 adults who were white, aged 60 years and older, and without baseline cognitive impairment had polygenic risk for dementia assessed and completed lifestyle questionnaires. A favorable lifestyle consisted of three or four of the following:

~Not currently smoking

~Regular physical activity (e.g., 150 min/week of moderate or 75 min/week of vigorous activity)

~Healthy diet

~Low-to-moderate alcohol intake (0-1 standard drink for women, 0-2 drinks for men)

During a median 8 years' follow-up, 0.9% were diagnosed with dementia. Both genetic risk and lifestyle were independently associated with dementia risk. Among those at high genetic risk, a favorable lifestyle was associated with an absolute risk reduction in dementia of 0.65%, compared with those who had an unfavorable lifestyle (0-1 factors).If the relationship is causal, the authors write, one case of dementia "would be prevented for each 121 individuals per 10 years with high genetic risk who improved their lifestyle from unfavorable to favorable."
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An article in Medical News Today (June 20, 2019) referring to a study in Neurology--"Computer Use in Later Life May Prevent Cognitive Decline":

http://bit.ly/30KQq80
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MISCELLANEOUS / Understanding masculinities to improve men's health (The Lancet)
« Last post by agate on July 19, 2019, 09:15:18 pm »
Many men don't take very good care of themselves, as is well known. It seems to be unmanly in their view of things to wear a hat and gloves in subzero weather--or to see a doctor about an ailment that they might have had for years.  Men don't live as long as women, on average, either. This article in The Lancet (July 20) points out that the situation needs more attention--"Understanding Masculinities to Improve Men's Health":


https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31609-5/fulltext?dgcid=raven_jbs_etoc_email
96
This article may be drug-company hype but it does reveal that ibudilast (MN-166) is going into a Phase 3 trial for use in SPMS without relapses--the type of SPMS that hasn't been expected to benefit from any of the MS drugs so far.


From the article:


Quote
We estimate the Phase 3 clinical trial for MN-166 in MS will begin in 2020 and approval will be in 2024, with peak sales of $5 billion approximately seven years after launch.



  MediciNova's plans for its Phase 3 trial of ibudilast for SPMS are described in this article from Yahoo Finance (July 18, 2019):


https://finance.yahoo.com/news/mnov-readying-phase-3-trial-200000909.html
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OCREVUS (ocrelizumab) / Re: My doctor thinks I should start taking Ocrevus
« Last post by agate on July 17, 2019, 07:02:24 am »
Sounds as if this went well!  Being able to do 90 minutes of yard work in the hot sun--that's amazing.


I hope the second dose goes well too!
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My infusion was done in a small hospital nearby. I wish my doctor would get an infusion pump.One of the nursed inferred that that was the reason.
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I was required to get tested for all forms of hepatitis prior to starting Ocrevus so now I know why. I was completely negative on all of them.
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OCREVUS (ocrelizumab) / Re: My doctor thinks I should start taking Ocrevus
« Last post by ewizabeth on July 17, 2019, 06:52:22 am »
I did a Google search for Ocrevus and your forum was one of the first pages of links Agate.  :) 


Well I started Ocrevus a week ago. I had the first half-dose. It went well, better than expected. My only reaction was a slight headache and that was likely from the steroids. They gave me a 250 mg drip, a long saline drip, extra strength Tylenol and 25 mg of Benadryl. I felt tired the first night when I got home but I kept drinking lots of water to help flush my system. The next day I felt wonderful from the steroids. I had no pains, lots of energy and a good mood. I got a lot of little jobs done around the house. The second day I was wiped out, sat around all day, tired as usual, and the third day all of my pain was back, business as usual.


Yesterday I had another good day like the day after the infusion. I even worked out in the yard for 90 minutes in the sun, heat, and humidity. I pulled lots of weeds and tended to the garden.


I get the second half dose next Wednesday, two weeks after the first. After that I'll be on the six month schedule. I'm really hopeful that this might even make me feel better.


I'm wondering if it has a whole body effect on inflammation when it wipes out the B cells. Because I've noticed an improvement in my IBS symptoms over that past few days.
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