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(Abst.) Recurrence of disease activity after ocrelizumab discontinuation in MS

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#1
This was a small study but it indicates that some people might have worsening MS if they stop taking Ocrevus....


From PubMed (October 7, 2024)--"The recurrence of disease activity after ocrelizumab discontinuation in multiple sclerosis":


We found focal inflammation after discontinuation of OCR in 4 (9.8 %) of the RRMS patients, of which 1 was radiologically confirmed. Our observations highlight that recurrence of focal inflammation...
PubMed · pubmed.ncbi.nlm.nih.gov
MS Speaks--online for 20 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week)  12/16/20 - 3/16/24.
#2
Another study on this topic.


From PubMed (January 21, 2026)--"Discontinuation of ocrelizumab in multiple sclerosis: Reoccurence of disease activity":


For stable pwMS, ocrelizumab discontinuation after about 30 months on-treatment appears safe short-term, though vigilant monitoring is warranted beyond 2 years off-treatment due to potential delaye...
PubMed · pubmed.ncbi.nlm.nih.gov
MS Speaks--online for 20 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week)  12/16/20 - 3/16/24.