Author Topic: Fulminant hepatitis associated w/Echovirus 25 during Ocrevus treatment...  (Read 88 times)

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Offline agate

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I may be giving too much attention to rare, anecdotal instances of adverse effects of the MS disease-modifying drugs, but here is another one. This MS patient was taking Ocrevus but ended up getting a liver transplant--and stopping the Ocrevus.  This is from JAMA Neurology (April 8, 2019), "Fulminant hepatitis associated with Echovirus 25 during treatment with ocrelizumab for multiple sclerosis":

This is from the discussion:

Because ocrelizumab is a novel, high-efficacy disease-modifying therapy for MS, it will probably be extensively used. However, it may impair clearance of enterovirus infections via B-cell depletion. Thus, in the case of compatible symptoms, tests should be conducted for enteroviruses. Given the bimodal clinical presentation (ie, the patient had a severe rebound of liver enzyme levels after initial improvement), patients receiving ocrelizumab with enteroviral infection need close follow-up.

MS Speaks--online for 14 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Generic Copaxone (glatiramer acetate) 40mg 3 times/week since 12/16/20.

Offline ewizabeth

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I was required to get tested for all forms of hepatitis prior to starting Ocrevus so now I know why. I was completely negative on all of them.


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