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Author Topic: Zinbryta (daclizumab) pulled from market due to safety concerns  (Read 282 times)

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Offline agate

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Zinbryta (daclizumab) pulled from market due to safety concerns
« on: March 02, 2018, 11:46:14 am »
Zinbryta is being taken off the market, according to MedPage Today (March 2, 2018):


https://www.medpagetoday.com/neurology/multiplesclerosis/71501?xid=NL_breakingnews_2018-03-02&eun=g378374d0r
« Last Edit: January 21, 2019, 09:49:11 pm by agate »
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Offline agate

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(Lancet editorial) End of the road for daclizumab in MS
« Reply #1 on: March 16, 2018, 12:36:35 pm »
An editorial in The Lancet (March 17, 2018) sums up the situation with Zinbryta (daclizumab), which has been taken off the market due to safety concerns:


http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30565-8/fulltext?{$trackingTag}
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SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week) since 12/16/20.

Offline agate

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FDA announcement about Zinbryta
« Reply #2 on: March 20, 2018, 04:28:01 pm »
The FDA notification about Zinbryta, which will be available until April 30:


https://www.fda.gov/Drugs/DrugSafety/ucm600999.htm
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Offline agate

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European EMA confirms severe risks associated w/MS drug Zinbryta
« Reply #3 on: May 23, 2018, 02:27:15 pm »
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SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week) since 12/16/20.

Offline agate

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(Abst.) DRESS syndrome and daclizumab failure--were dangerous signs missed in clinical trials?
« Reply #4 on: July 18, 2018, 11:19:19 am »
More on the failure of Zinbryta--from PubMed, July 18, 2018--DRESS syndrome and daclizumab failure--Were potentially dangerous signs missed in clinical trials?":


https://www.ncbi.nlm.nih.gov/pubmed/30013311




DRESS syndrome = drug reaction with eosinophilia and systemic symptoms


This case history (see link below) goes into more detail about DRESS syndrome--appearing in Neurology (September 1, 2018) under the title "Drug reaction with eosinophilia after daclizumab therapy in MS":


http://nn.neurology.org/content/5/5/e479








« Last Edit: July 18, 2018, 11:20:56 am by agate »
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Offline agate

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(Abst.) Case of immune-mediated encephalitis related to daclizumab therapy
« Reply #5 on: August 04, 2018, 07:00:52 am »

From PubMed (August 4, 2018). The same issue of Multiple Sclerosis Journal, which is where the article appears, includes an article entitled "Immune-mediated encephalitis with daclizumab: The final nail."  The article below is entitled "A case of immune-mediated encephalitis related to daclizumab therapy."

https://www.ncbi.nlm.nih.gov/pubmed/30073905
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Offline agate

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(Abst.) Severe meningo-encephalitis after daclizumab therapy for MS
« Reply #6 on: January 21, 2019, 09:48:42 pm »

The study concerns 7 patients, 2 of whom died. From Multiple Sclerosis Journal (January 19, 2019)--"Severe meningo-/encephalitis after daclizumab therapy for multiple sclerosis."

https://journals.sagepub.com/doi/abs/10.1177/1352458518819098
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Offline agate

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Daclizumab-induced encephalitis in MS
« Reply #7 on: September 25, 2019, 08:39:04 pm »
Editorial in Multiple Sclerosis Journal (September 24, 2019)--"Daclizumab-induced encephalitis in multiple sclerosis":


https://journals.sagepub.com/doi/full/10.1177/1352458519845079
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