Author Topic: Intrathecal Rituximab not effective in progressive MS  (Read 81 times)

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Offline agate

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Intrathecal Rituximab not effective in progressive MS
« on: March 14, 2016, 12:22:55 pm »
From the MS International Federation, March 14, 2016:

Intrathecal Rituximab is not effective in progressive multiple sclerosis

A recent study has failed to show any benefit for Rituximab in people with secondary progressive MS

MS affects brain cells. In contrast to cells of other organs, brain cells are not in close contact with blood, and nutrients or immune cells that are prevalent in blood need to cross barriers with the help of intermediate cells in order to reach brain cells.

For a long time, researchers have been looking at a shortcut to the environment where brain cells have direct access. Injections into spinal membranes from the lower back of the body (intrathecal) rather than injections into veins (intravenous), can provide this shortcut.

Rituximab is an injectable drug effective in autoimmune diseases by deactivating special immune cells of the body. Researchers tested whether giving Rituximab direct access to the brain environment could help people with MS.

The results of this study on a limited number of people with secondary-progressive MS, however, failed to show any benefit for Rituximab and the study was discontinued. This study tells us why this family of drugs (known as monoclonal antibodies) have poor results when administered intrathecally in progressive MS.

MS Speaks--online for 13 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010.


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