Author Topic: Mayzent (siponimod, BAF312) for active SPMS, RRMS  (Read 388 times)

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Offline agate

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Studies are busily being done on the cost effectiveness of siponimod, to be known as Mayzent, according to this blog post from Multiple Sclerosis News Today (March 20, 2019)--"SPMS treatment with Mayzent could be cost-effective, ICER report says":


https://multiplesclerosisnewstoday.com/2019/03/20/icer-report-spms-treatment-mayzent-could-be-cost-effective/




MS Speaks--online for 13 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010.

Offline agate

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The FDA has approved Mayzent (siponimod) but not for "inactive SPMS"--that is, SPMS without relapses. The MSAA has this informative article about it (March 27):


https://mymsaa.org/news/mayzent-fda-approved/?utm_source=latest_news&utm_medium=email&utm_campaign=mayzent_approval&utm_content=email_body


Mayzent is scheduled to become available in the first week of April.
« Last Edit: March 27, 2019, 04:29:05 pm by agate »
MS Speaks--online for 13 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010.

Offline agate

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Novartis prices Mayzent at $88K/year
« Reply #17 on: March 28, 2019, 02:21:45 pm »
More on this in SeekingAlpha, March 27, 2019:


https://seekingalpha.com/news/3446145-novartis-prices-ms-med-mayzent-88k-year



Someone on another site stated that Mayzent (siponimod) is the generic form of Gilenya (fingolimod). This article (see link) states:


Quote
Siponimod, a synthetic derivative of fingolimod, is designed for an improved safety profile, including less deleterious effects on heart rate and nerves.


Is a "synthetic derivative" the same as a generic form?
MS Speaks--online for 13 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010.

Offline agate

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Dr. Fox of the Cleveland Clinic was interviewed about Mayzent in Multiple Sclerosis News Today (April 3, 2019):


http://tinyurl.com/y5mmv2vx


« Last Edit: April 05, 2019, 02:42:40 pm by agate »
MS Speaks--online for 13 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010.

Offline agate

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Dr. Fox of the Cleveland Clinic is quoted in this article as well. Though it isn't always clear from the article, people who have had SPMS that hasn't been active for 2 years probably aren't going to be helped by Mayzent. From Multiple Sclerosis News Today (April 9, 2019)--"Mayzent 'Will Change Lives' of MS Patients Moving to SPMS, Novartis Says":


http://bit.ly/Mayzent




« Last Edit: April 09, 2019, 08:21:05 am by agate »
MS Speaks--online for 13 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010.

Offline agate

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  • MS diagnosed 1980
  • Location: Pacific Northwest

Mayzent (siponimod) may eventually be considered appropriate for persons with SPMS who are no longer having relapses, or at least this study indicates that some modest improvement in cognitive processing speed occurred in a trial involving some of these people. From Multiple Sclerosis News Today (July 2, 2019)--"Mayzent Boosts Cognitive Processing Speed in SPMS Patients, Phase 3 Trial Data Show":

http://bit.ly/2Lcv3sG
MS Speaks--online for 13 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010.

 

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