Author Topic: (Abst.) Extensive white matter lesions after 2 yrs. of fingolimod: PML or MS relapse?  (Read 88 times)

0 Members and 0 Guests are viewing this topic.

Offline agate

  • Administrator
  • *****
  • Posts: 8218
  • MS diagnosed 1980
  • Location: Pacific Northwest
From Multiple Sclerosis Journal, December 23, 2016:

Quote
Extensive white matter lesions after 2 years of fingolimod: Progressive multifocal leukoencephalopathy or MS relapse?


Marine Boudot de la Motte, Céline Louapre, Anne Bertrand, Pauline Reach, Catherine Lubetzki, Caroline Papeix, Elisabeth Maillart


Background:

Fingolimod is a widely used treatment for highly active relapsing–remitting multiple sclerosis.

Objectives:

To describe the case of a 27-year-old patient treated for more than 2 years by Fingolimod, who presented hemiplegia and speech disturbances associated with extensive white matter lesions on brain magnetic resonance imaging (MRI).

Methods:

Case study.

Results:

Although initial presentation questioned the possibility of progressive multifocal leukoencephalopathy, final diagnosis was multiple sclerosis (MS) relapse. Appropriate treatment resulted in clinical and radiological improvement.

Conclusion:

Severe MS relapses under Fingolimod have been reported, but late onset after treatment initiation and extensive subcortical topography is unusual and represents a diagnostic challenge.

MS Speaks--online for 13 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010.

 

Related Topics

  Subject / Started by Replies Last post
0 Replies
38 Views
Last post August 18, 2016, 04:28:15 pm
by agate
0 Replies
43 Views
Last post December 24, 2017, 02:04:09 pm
by agate
0 Replies
53 Views
Last post March 16, 2018, 11:51:28 am
by agate
0 Replies
10 Views
Last post June 20, 2019, 09:06:16 pm
by agate
2 Replies
36 Views
Last post August 29, 2019, 09:23:46 pm
by agate