Author Topic: (Abst.) Extensive white matter lesions after 2 yrs. of fingolimod: PML or MS relapse?  (Read 75 times)

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Offline agate

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From Multiple Sclerosis Journal, December 23, 2016:

Extensive white matter lesions after 2 years of fingolimod: Progressive multifocal leukoencephalopathy or MS relapse?

Marine Boudot de la Motte, Céline Louapre, Anne Bertrand, Pauline Reach, Catherine Lubetzki, Caroline Papeix, Elisabeth Maillart


Fingolimod is a widely used treatment for highly active relapsing–remitting multiple sclerosis.


To describe the case of a 27-year-old patient treated for more than 2 years by Fingolimod, who presented hemiplegia and speech disturbances associated with extensive white matter lesions on brain magnetic resonance imaging (MRI).


Case study.


Although initial presentation questioned the possibility of progressive multifocal leukoencephalopathy, final diagnosis was multiple sclerosis (MS) relapse. Appropriate treatment resulted in clinical and radiological improvement.


Severe MS relapses under Fingolimod have been reported, but late onset after treatment initiation and extensive subcortical topography is unusual and represents a diagnostic challenge.

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SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010.


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