Cladribine (Mavenclad) approved for active SPMS, RRMS on: April 01, 2019, 04:00:21 pm #1 Another MS drug has been approved. Like siponimod (Mayzent), it turns out to be for SPMS only if it's still active SPMS (still having relapses). From the MSAA (April 1, 2019): Mavenclad® (Cladribine) Tablets Approved by the FDA for Adults with Relapsing Forms of MS, Including Active SPMS | MSAA The approval is for individuals with relapsing-remitting MS (RRMS) and for individuals with active secondary-progressive MS (SPMS). MSAA · mymsaa.org Logged MS Speaks--online for 20 yearsSPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week) 12/16/20 - 3/16/24.