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(JAMA) Rituximab vs ocrelizumab in RRMS

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(JAMA) Rituximab vs ocrelizumab in RRMS
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#1

From JAMA Neurology (June 12, 2023)--"Rituximab vs Ocrelizumab in Relapsing-Remitting Multiple Sclerosis":


https://bit.ly/43BuNIb
MS Speaks--online for 20 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week)  12/16/20 - 3/16/24.
Ocrevus appears better than rituximab at preventing MS relapses
Reply #1 on:
#2
From Multiple Sclerosis News Today (June 14, 2023)--"Ocrevus appears to be better than rituximab at preventing MS relapses":


Ocrevus is more effective than rituximab at reducing relapse activity of RRMS, while disability progression is comparable, a study suggests.
Multiple Sclerosis News Today · multiplesclerosisnewstoday.com
MS Speaks--online for 20 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week)  12/16/20 - 3/16/24.
#3
This JAMA editorial discusses this study.


From JAMA (June 12, 2023), "New Approaches to Challenge Old Assumptions:  B-Cell Depletion in Multiple Sclerosis":


https://bit.ly/3p9SU1D
MS Speaks--online for 20 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week)  12/16/20 - 3/16/24.
#4
Some MS researchers have written a letter about the article mentioned in the first post in this thread, and the author of that article has replied.


In JAMA Neurology (November 20, 2023), "Comment and Response"--"Comparative efficacy of disease-modifying treatments for multiple sclerosis--Variations in real-world experience":


https://bit.ly/3SR9zn0


And the author's reply in the same issue:


https://tinyurl.com/mtrwpcxt
MS Speaks--online for 20 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week)  12/16/20 - 3/16/24.
#5
And then there is the matter of the comparative cost of these two drugs.


From JAMA (Research Letter, November 27, 2023)--"Potential Medicare and Medicaid savins on anti-CD20 therapy for multiple sclerosis":


https://tinyurl.com/v3zknrnn
MS Speaks--online for 20 years

SPMS, diagnosed 1980. Avonex 2001-2004. Copaxone 2007-2010. Glatopa (glatiramer acetate 40mg 3 times/week)  12/16/20 - 3/16/24.