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THE PRACTICAL SIDE OF BEING MULTIPLY SCLEROSED / Some falls are lucky
« Last post by agate on November 25, 2025, 09:31:34 pm »
Falling is so much a part of the "MS experience" that they often seem unremarkable to anyone with MS or to family members dealing with a relative with MS.


But there are falls that injure, and then there are the very very fortunate falls that don't.


Today I fell and it seems to have been one of those rare lucky falls with no serious damage. I don't know how I managed it, but I'm going to keep up with my exercises, just in case they're helping me to fall less harmfully.


I was in the kitchen putting the finishing touches on dinner. I had turned off the oven and the burner on the stove. I was holding an empty but hot saucepan.  Suddenly, as has happened twice before, my left side buckled and I went down.


Some things went flying onto the floor. I knocked over the waste basket too. But no food was spilled, and I was able to get up easily enough by hanging onto the edges of the double sink. I went right on with dinner and was hardly shaken up at all.


I took a couple of Tylenol later to stave off some aches that were starting up. Tomorrow things might be worse but I hope not.


However, I wasn't able to get around to finding anything else to post here today.  Maybe some people will be interested in knowing that there are falls that aren't so injurious. I don't recommend any falls but some of them don't result in a fracture or bruises or a disoriented feeling.
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From PubMed (November 24, 2025)--"Non-pharmacological interventions for fecal incontinence in people with multiple sclerosis: A scoping review":


https://pubmed.ncbi.nlm.nih.gov/41275837/
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THE PRACTICAL SIDE OF BEING MULTIPLY SCLEROSED / Re: MSAA MRI Access Fund resumes
« Last post by agate on November 23, 2025, 09:14:06 pm »
According to this notice (November 3, 2025), the MSAA's program offering free access to MRIs for those who qualify is back:


https://mymsaa.org/msaa-help/mri/?utm_medium=email&utm_source=newsletter&utm_campaign=mri&utm_content=V10N6
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MISCELLANEOUS / Bad gums tied to big brain risks
« Last post by agate on November 21, 2025, 09:35:23 pm »
From MedPage Today (October 22, 2025):

Bad Gums Tied to Big Brain Risks
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MS - RESEARCH AND NEWS / Re: MSAA MS research update - November
« Last post by agate on November 20, 2025, 03:21:49 pm »
MSAA research updates-- November (November 18, 2025):
What's New in MS Research--November 2025
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MISCELLANEOUS / Language issues--"couple"
« Last post by agate on November 20, 2025, 11:21:14 am »
The last I heard, couple isn't an adjective. It can't modify a noun or a pronoun. And  yet many people now think it can, as in this e-mail message I received today:


Quote
... Cigna Group, which owns the second-largest PBM Express Scripts, announced it will phase out prescription drug manufacturer rebates over the next couple years.

This usage has become so common that it is probably in danger of becoming accepted into the language. But it contributes to a general blurring of a language that has a certain amount of valuable precision built into it.

Please bring back couple of.
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Abstract of research presented at the annual ECTRIMS meeting (2025):


P1954 Neighborhood-Level Socioeconomic Disadvantage and Clinical Care Characteristics in Multiple Sclerosis

Jagriti "Jackie" Bhattarai, Miranda Jones, Abbey Hughes

Johns Hopkins University School of Medicine, Baltimore, United States, Johns Hopkins University Bloomberg School of Public Health, Baltimore, United States

Introduction:


Socioeconomic disadvantage is a known contributor to disparities among individuals with multiple sclerosis (MS), yet its association with variations in MS clinical care characteristics has yet to be explored. Clinical care represents an opportunity to reduce disparities by promoting consistent, high-quality care across all patients with MS and warrants empirical investigation.


Objectives/Aims:

Quantify differences in MS clinical care characteristics among patients based on neighborhood-level socioeconomic disadvantage.

Methods:


Data from medical records across four MS clinical encounters obtained from retrospective chart review were analyzed among US patients with MS. Patient addresses were linked with the census-block Area of Deprivation Index (ADI). Odds ratios (OR) for the evaluation of MS care characteristics comparing ADI tertiles were quantified using multivariable logistic regression.

Results:

Participants (N=260; mean age 51.3 [SD=12.2]) were mostly female (78%) and identified as Black (51%) or White (49%). Participants in the highest ADI tertile (greatest socioeconomic disadvantage) were more likely to be Black (59% v 41%), whereas those in the lowest tertile (lowest socioeconomic disadvantage) were more likely to be White (61% v 39%). Compared to individuals in lowest ADI tertile, individuals in the highest tertile were less likely to be evaluated for mood (OR=0.39, 95% CI [0.18, 0.87]) and sleep (OR=0.31, 95% CI [0.16, 0.63]) across encounters. Among lifestyle factors, participants in the highest ADI tertile were less likely to be evaluated for diet/nutrition (OR=0.48, 95% CI [0.25, 0.92]) and physical activity (OR=0.40, 95% CI [0.17, 0.95]), yet they had 3.80 (95% CI [1.16, 12.52]) higher odds of being evaluated for smoking status. Although nonsignificant, encounters for individuals in higher ADI tertiles were less likely to include cognitive evaluation, MRI review, and level 5 care, whereas they had higher odds (3.91) of being evaluated for an MS relapse.

Conclusion:

There were noteworthy differences in MS clinical care characteristics based on neighborhood-level socioeconomic disadvantage, such that participants residing in more disadvantaged neighborhoods were less likely to be evaluated for certain MS symptoms and lifestyle factors, while being almost four times more likely to be evaluated for smoking status. Similar trends were found with respect to the remaining MS symptoms and clinical care practices. Additional research is needed to more fully understand the role of clinician and patient factors in these differences. Based on our findings, continued efforts to standardize aspects of the MS clinical visit and provider training to increase awareness of these trends may offer opportunity to reduce existing disparities in MS care.

Disclosure of interest:


Jagriti “Jackie” Bhattarai: nothing to disclose. Miranda R. Jones: nothing to disclose. Abbey J. Hughes: nothing to disclose.
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More on this--in PubMed (November 18, 2025)--"Promising effects of CAR-T-cell therapy in refractory stiff person syndrome and a hopeful future for all neuroautoimmunities":


https://pubmed.ncbi.nlm.nih.gov/41248446/
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TYRUKO (natalizumsb-sztn) / Tyruko--first biosimilar to treat MS--now available
« Last post by agate on November 17, 2025, 03:25:53 pm »

From Managed Health Care Executive (November 17, 2025)--"Tyruko, the first biosimilar to treat multiple sclerosis, is now available":


https://www.managedhealthcareexecutive.com/view/tyruko-the-first-biosimilar-to-treat-multiple-sclerosis-is-now-available
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